(= 12, excluding E578Q (= 6). tested thus far can form stable hexamers (19, 20) and show improved D2 ATPase activity (19C23). Disease mutations lead to Mcl1-IN-4 improved proteolytic susceptibility of the D2 ring (19). Structural and biochemical studies suggest that disease mutations alter N-domain and D1 conformations (20, 23, […]